Fig. 3.

Glucose metabolism and insulin sensitivity

Panel a: Mean ± SEM glucose infusion rate during the hyperinsulinemic euglycemic glucose clamp (HEC), expressed as M value, before (pre) and after (post) disease control. Panel b: Endogenous glucose production (EGP) in the basal state (black bars) and during the HEC (grey bars) before (pre) and after (post) disease control. Panel c: Mean ± SEM adipose tissue insulin resistance (Adipo-IR) before (pre) and after (post) disease control. Disease control increased insulin sensitivity in muscle (a), liver (b) and adipose tissue (c). P* reflects the effect of disease control on EGP in the basal state and P** during the HEC.