Table 4.
Glucose metabolism
| Pre | Post | Δ SA | Δ Surgery | |
|---|---|---|---|---|
| OGTT | ||||
| Fasting (mmol/L) | 5.76 (5.27; 6.30) | 5.32 (4.86; 5.83) | 0.41 (-0.19; 1.02) | -1.30 (-2.83; 0.23) b |
| 210 min (mmol/L) | 7.79 (6.39; 9.19) | 7.51 (6.08; 8.93) | 1.14 (-0.09; 2.37) | -1.64 (-3.96; 0.68) b |
| Peak (mmol/L) | 10.37 (9.29; 11.57) | 10.11 (9.05; 11.31) | 0.84 (-0.83; 2.51) | -1.31 (-3.80; 1.18) |
| AUC0–210, (mmol/L⋅min) | 1628 (1467; 1807) | 1553 (1397; 1726) | 121.5 (-89.9; 332.9) | -290.1 (-750.1;169.9) b |
| RdGlu (mg/kg/min) | ||||
| Basal | 2.03 (1.37; 2.69) | 1.57 (.94; 2.20) | -0.16 (-0.86; 0.53) | -0.86 (-1.05; -0.36) |
| HEC | 4.28 (3.60; 4.96) | 5.37 (4.74; 6.00)a | 0.61 (-0.13;1.36) | 1.77 (1.04; 2.50) |
| RaGlu (mg/kg/min) | ||||
| Basal | 1.95 (1.22; 2.67) | 1.43 (.74; 2.12) | -0.33 (.-0.98; 0.33) | -0.67 (-1.01; -0.32) |
| HEC | 3.97 (3.23; 4.72) | 4.94 (4.25; 5.63)a | 0.45 (-0.34; 1.25) | 1.87 (0.84; 2.91) |
| Glucose oxidation (mg/kg/min) | ||||
| Basal | 1.08 (.82; 1.43) | .95 (.71; 1.26) | 0.05 (-1.63; 1.73) | -0.25 (-0.88;0.39) |
| HEC | 1.67 (1.26; 2.22) | 1.61(1.21; 2.13) | -0.39 (-1.08; 0.31) | -0.27 (-1.44; 0.91) |
| Non-oxidative glucose disposal (mg/kg/min) | ||||
| Basal | 0.59 (-0.08; 1.26) | 0.41 (-0.23; 1.06) | 0.61 (-0.99; 2.20) | -0.43 (-1.29; 0.43)b |
| HEC | 1.94 (1.27; 2.61) | 3.09 (2.47; 3.71)a | 0.82 (-0.78; 2.43) | 1.96 (0.48; 3.45) |
| FGU (µmol/100mL/min) | ||||
| Basal | 0.19 (0.11; 0.34) | 0.18 (0.10; 0.30) | -0.05 (-0.30; 0.19) | -0.09 (-0.30; 0.12) |
| HEC | 0.62 (0.40; 0.98) | 1.86 (1.16; 2.97)a | 1.82 (0.21; 3.43) | 0.59 (-1.04; 2.23) b |
*Patients treated with pegvisomant are excluded for evaluation of treatment modality in the analysis of OGTT data.
Glucose metabolism before (pre) and after (post) disease control, and according to treatment modality (Somatostatin Analogue (SA) and Surgery) presented as the change (Δ) from first to second visit. Glucose tolerance was evaluated during an oral glucose (75g) tolerance test. Glucose turnover parameters were determined by [3-3H]-glucose tracer infusion in the basal and HEC periods: RdGlu, Rate of glucose disappearance; RaGlu, Rate of glucose appearance. FGU, forearm glucose disposal. Data are presented as median (CI).
a
P < 0.05 for pre total vs post total.
b
P < 0.05 for Δ pre-post, SA vs. surgery.