Table 2.
Functional connectivity group differences. MNI coordinates; Significant level at p < 0.05 pFWE corrected on the cluster level. Nine clusters presented significant group differences (OCD vs. HC) for seed regions of the DMN, and the SN. After additional Bonferroni correction for the number of seed-to-voxel analyses, three clusters based on DMN seeds remained significant: right and left lateral parietal (LP_r/l) to the left occipital pole (OP_l) and LP_r to a cluster comprised the right superior Lateral Occipital Cortex (sLOC_r) and the precuneus.
| Seed | Peak of cluster (x, y, z) | K | Cluster level pFWE | pFWE*30 seeds | Cluster location | T-value |
|---|---|---|---|---|---|---|
| DMN | . | |||||
| Lateral ParietalLeft (LP_l) |
(−32–94 −02) | 677 | <0.001 | <0.001 | OP_l (Occipital Pole Left); iLOC_l (Lateral Occipital Cortex, inferior division Left) | −5.28 |
| (+26–60 + 50) | 195 | 0.035 | NS | sLOC_r (Lateral Occipital Cortex, superior division Right); Precuneous (Precuneous Cortex) | 4.66 | |
| Lateral ParietalRight (LP_r) |
(−34–94 −04) | 486 | <0.001 | 0.006 | OP_l (Occipital Pole Left); iLOC_l (Lateral Occipital Cortex, inferior division Left) | −4.88 |
| (+24–54 + 40) | 450 | <0.001 | 0.01 | sLOC_r (Lateral Occipital Cortex, superior division Right); Precuneous (Precuneous Cortex) | 5.09 | |
| (−28–36 + 42) | 203 | 0.028 | NS | SPL _l (Superior Parietal Lobule Left); sLOC_l (Lateral Occipital Cortex, superior division Left) | 4.92 | |
| Posterior CingulateCortex (PCC) |
(+02–82 + 34) | 181 | 0.041 | NS | Cuneal_r (Cuneal Cortex Right); Cuneal_l (Cuneal Cortex Left); OP_l (Occipital Pole Left) | −4.76 |
| SN | ||||||
| Anterior CingulateCortex (ACC) |
(+40–86 −12) | 353 | 0.002 | NS | iLOC_r (Lateral Occipital Cortex, inferior division Right); OP_r (Occipital Pole Right) | 4.9 |
| Insula_l | (+50–74 −06) | 265 | 0.007 | NS | iLOC_r (Lateral Occipital Cortex, inferior division Right) | 4.80 |
| Insula_r | (+22–54 + 20) | 291 | 0.005 | NS | Precuneous (Precuneous Cortex) | −5.02 |