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. 2021 Oct 23;13(2):517–540. doi: 10.1016/j.jcmgh.2021.10.008

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Copy number alterations (CNAs) of CT–PDTOs and PDTOs. The depicted CNA plots of PDTOs and CT–PDTOs in comparison with normal diploid tissue (NT) were derived from next-generation sequencing data (whole-exome sequencing). (A–C) PDTOs and CT–PDTOs were compared with diploid normal tissues. Note the pronounced genomic amplifications, indicated in red, of chromosome 20 regions containing the AURKA-encoding 20q13.2 locus. Amplification scores of the AURKA-encoding chromosomal region are indicated above the CNA plots. (D) Two NT samples showing no chromosomal alterations when compared with each other.