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. 2021 Dec 7;12:743890. doi: 10.3389/fimmu.2021.743890

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Copyright © 2021 Nieto-Fontarigo, Tillgren, Cerps, Sverrild, Hvidtfeldt, Ramu, Menzel, Sander, Porsbjerg and Uller

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of imiquimod treatment on SARS-CoV-2 receptor expression and IFN response in human bronchial epithelial cells (HBECs) from asthmatics. Imiquimod effect on the mRNA expression of ACE2 (A) and TMPRSS2 (B) in HBECs from asthmatic patients. (C–F) Imiquimod effect on the anti-viral response of bronchial epithelium. IFN-β mRNA expression (C), as well as the pattern recognition receptors TLR3 (D), MDA5 (E), and RIG-I (F) are shown. HBECs from study population 1 and 2 were used, N = 16-18. Wilcoxon Signed Rank Test. ns, not significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.