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. 2021 Dec 7;12:743890. doi: 10.3389/fimmu.2021.743890

Table 2.

Reactome pathways overrepresentation against whole human genome.

Observed Expected Fold Enrichment FDR
Immune System (R-HSA-168256) 16 2.62 6.11 2.89E-02
Cytokine Signaling in Immune system (R-HSA-1280215) 10 1.00 10.01 4.07E-07
Hemostasis (R-HSA-109582) 7 .81 8.62 4.00E-02
Innate Immune System (R-HSA-168249) 7 1.34 5.22 5.17E-03
Transcriptional Regulation by RUNX3 (R-HSA-8878159) 4 .11 35.43 4.43E-02
Interferon Signaling (R-HSA-913531) 4 .24 16.81 2.49E-02
Apoptosis (R-HSA-109581) 4 .21 19.27 3.60E-02
Interferon Gamma Signaling (R-HSA-877300) 3 .11 27.16 1.51E-02
Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807) 3 .13 22.26 1.26E-02
Transcriptional regulation by RUNX2 (R-HSA-8878166) 3 .14 21.12 4.27E-02
Interleukin-27 Signaling (R-HSA-9020956) 2 .01 >100 3.08E-03
Interleukin-35 Signaling (R-HSA-8984722) 2 .01 >100 2.36E-05
IL-6-type Cytokine Receptor Ligand Interactions (R-HSA-6788467) 2 .02 96.92 1.56E-02
Interleukin-20 Family Signaling (R-HSA-8854691) 2 .03 65.90 1.71E-02
Antigen Presentation: Folding, Assembly and Peptide Loading of Class I MHC (R-HSA-983170) 2 .03 63.37 2.72E-02