Table 3.
Key baseline parameters and changes during follow-up stratified by tertile of longitudinal RA function.
| Characteristics | RA peak longitudinal strain tertile | |||
|---|---|---|---|---|
| Worsened (n = 19) | Stable (n = 18) | Improved (n = 19) | p value | |
| Baseline | ||||
| BNP, pg/ml | 106 [88–220] | 182 [44–559]* | 160 [62–429] | 0.797 |
| Mean pulmonary arterial pressure, mm Hg | 41 ± 10 | 40 ± 9 | 46 ± 11 | 0.187 |
| Right atrial pressure, mm Hg | 8 [5–9] | 8 [6–13] | 8 [6–10] | 0.508 |
| Pulmonary vascular resistance, Wood Units | 7 ± 3 | 7 ± 3 | 9 ± 3 | 0.178 |
| Cardiac index, l/min/m2 | 2.4 ± 0.4 | 2.5 ± 0.6 | 2.3 ± 0.5 | 0.399 |
| Pulmonary arterial capacitance, ml/mmHg | 1.4 [1.1–2.3] | 1.6 [1.1–1.9] | 1.4 [0.9–1.9] | 0.624 |
| RV end-diastolic area, cm2 | 23 [18–29] | 28 [23–35] | 28 [25–32] | 0.095 |
| RV end-systolic area, cm2 | 18 [12–22] | 18 [17–20] | 22 [17–27] | 0.131 |
| Fractional area change, % | 27 ± 8 | 24 ± 14 | 24 ± 10 | 0.655 |
| TAPSE/PASP, mm/mmHg | 0.29 [0.22–0.40] | 0.31 [0.21–0.46] | 0.28 [0.18–0.41] | 0.668 |
| RV global longitudinal strain, % | −17.2 ± 3.7 | −13.1 ± 5.5 | −14.7 ± 4.3 | 0.050 |
| RA area, cm2 | 17 [14–20] | 18 [17–20] | 18 [14–22] | 0.288 |
| Δ During follow-up | ||||
| Δ Mean pulmonary arterial pressure, mm Hg | 2 ± 10† | −7 ± 11 | −8 ± 8† | 0.039 |
| Δ Pulmonary arterial capacitance, ml/mm Hg | −0.02 [−0.53–0.27]† | 0.63 [−0.11–1.00] | 0.88 [0.36–1.4]† | 0.006 |
| Δ Pulmonary vascular resistance, Wood Units | −0.1 ± 3.0† | −2.4 ± 3.7 | −4.2 ± 2.8† | 0.009 |
| Δ BNP, pg/ml | 0 [−71–68] | −61 [−154–6]§ | −83 [−305 to −21] | 0.015 |
| Δ TAPSE/PASP | −0.02 [−0.08–0.02] | 0.04 [−0.04–0.14]* | 0.09 [0.03–0.17] | 0.018 |
| Δ RA area, cm2 | 1 ± 7 | −3 ± 4 | −3 ± 5 | 0.083 |
| Δ RV end-diastolic area, cm2 | −2 ± 6* | −4 ± 3 | −5 ± 5 | 0.103 |
| Δ RV end-systolic area, cm2 | −1 ± 4 | −5 ± 4 | −6 ± 5 | 0.005 |
| Δ Fractional area change, % | 1 ± 11¶ | 6 ± 13 | 7.1 ± 15 | 0.271 |
| Δ RV global longitudinal strain, % | −1.7 [−3.7 to −0.7]* | 1.2 [−0.9–4.8] | 4.6 [2.6–5.8] | <0.001 |
Δ, change; BNP, B-type natriuretic peptide; PASP, pulmonary arterial systolic pressure; RA, right atrial; RV, right ventricular; TAPSE, tricuspid annular plane systolic excursion.
Values represent mean ± SD or median (interquartile range) (for normally or non-normally distributed parameters, respectively), unless otherwise specified.
*Available in 17 patients.
Available in 13 patients.
Available in 12 patients.
§Available in 16 patients.
¶Available in 18 patients.