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. 2021 Dec 7;9:791119. doi: 10.3389/fbioe.2021.791119

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Copyright © 2021 Gundogdu, Okhunov, Starek, Veneri, Orabi, Holzman, Sullivan, Khoury and Mauney.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cavernosometric and cavernosographic evaluations of control and reconstructed penile tissues. (A) Representative intracorporal pressure (ICP) tracings from NSC and animals repaired with BLSF, TV, or SIS implants and assessed at 3 months post-op. (B) Maximum ICP levels achieved in experimental groups described in (A). Values are presented as means ± SD. N = 3–5 replicates per data point. Results from all groups were analyzed with Kruskal–Wallis test yielding p > 0.05. (C) Representative photomicrographs of penile erections and cavernosographic findings at maximum ICP levels following contrast instillation for groups described in (A). NSC, nonsurgical controls; BLSF, bi-layer silk fibroin scaffold; TV, tunica vaginalis; SIS, small intestinal submucosa.