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. 2021 Dec 7;12:753929. doi: 10.3389/fimmu.2021.753929

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Copyright © 2021 Li, Chen, Yin, Song, Jiang, Tang, Fan, Xu, Wang, Xue, Han, Wang, Li and Zhong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening of differentially expressed genes encoding extracellular proteins. (A) The genes encoding extracellular proteins annotated in the HPA database were intersected with DEGs, 69 EP-DEGs were screened out. The genes encoding extracellular proteins annotated in the Uniprot database were intersected with DEGs, 132 EP-DEGs were screened out. The genes screened by the two methods were combined to obtain a total of 133 EP-DEGs. (B) Volcano map of EP-DEGs in MS group and control group. Mark the top 10 up-regulated and down-regulated genes with the smallest P-value. (C) Heatmap of the top 30 up-regulated and down-regulated EP-DEGs.