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. 2021 Dec 7;12:753929. doi: 10.3389/fimmu.2021.753929

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Copyright © 2021 Li, Chen, Yin, Song, Jiang, Tang, Fan, Xu, Wang, Xue, Han, Wang, Li and Zhong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of PPI network of EP-DEGs and screening of hub genes. (A) The STRING database is used to construct the PPI network of EP-DEGs, with 85 nodes and 185 edges (the legend is in the Supplementary Material ). (B) The node gene cluster with the highest score constructed by the MCODE plug-in in Cytoscape consists of 9 genes. (C) The Cytohubba is used to construct the Top10 hub genes. The figure shows the Top10 hub genes constructed by the MCC method. (D) The Cytohubba was used to predict the first stop node genes that interact with IL17A. A total of 16 genes were predicted, 10 up-regulated and 6 down-regulated.