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. 2021 Apr 19;28(1):29–48. doi: 10.1177/13524585211008760

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© The Author(s), 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Reported preclinical models (a) and clinical trial phases (b) used to evaluate remyelinating and/or neuroprotective interventions for MS. Among the 221 included articles, a total of 250 animal model studies and 19 clinical studies were reported. Descriptions of each study type are included in Supplementary Table S4.

EtBr: ethidium bromide; EAE: experimental autoimmune encephalomyelitis; LPC: lysophosphatidylcholine; MHV: murine hepatitis virus; TMEV: Theiler’s murine encephalomyelitis virus.