TABLE 2.
Proteases and protease inhibitors significantly elevated in Sjogren’s Syndrome (SS) tear wash over healthy controls.
| Uniprot ID | Gene name | Protein name | Fold difference SS/healthy |
|---|---|---|---|
| Elevated in Sjogren’s Syndrome | |||
| P14780 | MMP9 | Matrix metalloproteinase-9 | 88.4 |
| P28325 | CST5 | Cystatin-D | 12.5 |
| P22894 | MMP8 | Neutrophil collagenase | 9.4 |
| P01034 | CST3 | Cystatin-C | 8.5 |
| P07858 | CTSB | Cathepsin B | 6.2 |
| P09960 | LTA4H | Leukotriene A-4 hydrolase | 5.3 |
| Q16651 | PRSS8 | Prostasin | 5.1 |
| Elevated in healthy | |||
| P07384 | CAPN1 | Calpain-1 | −21.8 |
| Q96KP4 | CNDP2 | Cytosolic non-specific dipeptidase | −17.7 |
| P01042 | KNG1 | Kininogen-1 | −12.4 |
| P08697 | SERPINF2 | Alpha-2-antiplasmin | −11.9 |
| Q99497 | PARK7 | DJ-1/Parkinson disease protein 7 | −11.6 |
| P60900 | PSMA6 | Proteasome subunit alpha type-6 | −10.6 |
| P25788 | PSMA3 | Proteasome subunit alpha type-3 | −10.6 |
| P13798 | APEH | Acylamino-acid-releasing enzyme | −9.3 |
| P25787 | PSMA2 | Proteasome subunit alpha type-2 | −9.0 |
| P28838 | LAP3 | Cytosol aminopeptidase | −8.5 |
| P30086 | PEBP1 | Phosphatidylethanolamine-binding protein | −7.6 |
| Q5JNW7 | PSMB8 | Proteasome subunit beta type-8 | −6.1 |
| P30740 | SERPINB1 | Leukocyte elastase inhibitor | −5.6 |