Table 1.

Generation of renal disease in recipient mice by the transfer of DOCK8⁺CD4 T cells

Donor	Transferred cell	Lupus nephritis WHO class
		I & II	III	IV	V
12x PBS	CD4 T cell	71.96 ±11.04%	28.03 ±11.04%	0%	0%
12x OVA	DOCK8- CD4 T cell	68.54 ±12.39%	29.31 ±12.75%	2.14 ±3.36%	0%
12x OVA	DOCK8+ CD4 T cell	18.77 ±9.40%∗∗	33.99 ±9.78%	31.89 ±17.04%∗	15.32 ±9.17%∗

Glomerulonephritis in BALB/c mice that had been pre-immunized 8x with OVA, depleted of CD4 T cells by anti-CD4 Ab, and inoculated with DOCK8⁻CD4 T cells or DOCK8⁺CD4 T cells from 12x OVA-immunized BALB/c mice. Control group was BALB/c mice that had been pre-immunized 8x with OVA, depleted of CD4 T cells by anti-CD4 Ab, and inoculated with CD4 T cells from 12x PBS-immunized BALB/c mice. Glomerular lesions in mice were classified according to human WHO classification (Weening et al., 2004) as follows; class I, normal glomeruli; class II, purely mesangial disease; class III, focal proliferative glomerulonephritis; class IV, diffuse proliferative glomerulonephritis; and class V, membraneous glomerulonephritis. Data were represented as mean ± SEM. Statistical assessment was by Student's t-test.

^∗p<0.05,vis 12x OVA DOCK8^- CD4 T cell and vis 12x PBS CD4 T cell.

^∗∗p<0.001, vis 12x OVA DOCK8^- CD4 T cell and vis 12x PBS CD4 T cell.