Table 2.
Summary of the lesions other than kidney in the BALB/c mice 8x pre-immunized with OVA, CD4 T cell-depleted, and inoculated with DOCK8−CD4 T cells or DOCK8+CD4 T cells from 12x OVA-immunized BALB/c mice
| Transferred cell: | 12x immunized with OVA |
Treatment with Ab |
||||
|---|---|---|---|---|---|---|
| DOCK8+ CD4+ | DOCK8- CD4+ | p∗ | Control IgG | Anti- DOCK8 Ab | p∗ | |
| Skin, dermatitis | 4/5 | 0/5 | 0.0476 | 4/5 | 0/5 | 0.0476 |
| Lung, interstitial pneumonitis | 4/5 | 1/5 | 0.206 | 4/5 | 0/5 | 0.0476 |
| Liver, pericholangitis | 2/5 | 0/5 | 0.444 | 2/5 | 1/5 | 0.1 < |
| Spleen, onion skin lesion | 5/5 | 0/5 | 0.0079 | 2/5 | 1/4 | 0.1 < |
| Thyroid, thyroiditis | 2/5 | 0/5 | 0.444 | 4/5 | 0/5 | 0.0476 |
| Thymus, cortex atrophy | 0/5 | 0/5 | 0/5 | 5/5 | 0.0079 | |
Also shown were the results from anti-DOCK8 Ab treatment of 12x OVA-immunized mice: Mice received 100μg of anti-DOCK8 Ab 24 h each before the 6x, 8x, 10x, and 12x OVA immunizations with OVA. ∗Statistical analysis was by Fisher's exact test.