Table 3.

Renal lesion of BALB/c mice immunized 12x with either PBS or OVA, and treated either with anti-DOCK8 Ab (100μg) or control rabbit IgG (100μg) 24 h each before the 6x, 8x, 10x, and 12x OVA immunizations with OVA

Immunized with	Treatment	Lupus nephritis WHO class
		I & II	III	IV	V
12x PBS	Control IgG (n = 3)	48.68 ±12.91%	28.05 ±9.45%	14.17 ± 3.72%	9.08 ± 3.01%
12x OVA	Control IgG (n = 6)	7.33 ±5.12%	18.33 ±7.34%	24.04 ±7.35%	50.28 ±7.62%
12x OVA	Anti-DOCK8 Ab (n = 6)	33.91 ±14.40%∗	36.37 ±6.98%	19.93 ±11.64%∗∗	9.70 ±8.78%∗∗

Glomerular lesions were classified according to human WHO classification (Weening et al., 2004) as follows; class I, normal glomeruli; class II, purely mesangial disease; class III, focal proliferative glomerulonephritis; class IV, diffuse proliferative glomerulonephritis; and class V, membraneous glomerulonephritis. Data were represented as mean ± SEM. Statistical assessment was by Student's t-test.

^∗p<0.005, vis control IgG treatment.

^∗∗p<0.001, vis control IgG treatment.