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. 2021 Dec 7;15:763235. doi: 10.3389/fnins.2021.763235

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Copyright © 2021 Arlotti, Colombo, Bonfanti, Mandat, Lanotte, Pirola, Borellini, Rampini, Eleopra, Rinaldo, Romito, Janssen, Priori and Marceglia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chronic LFP recordings in the embedded mode: Left side: Time-frequency plots of six representative hours. The x-axis represents time and the y-axis frequency (from 5 to 35 Hz). The colored dots (blue, red, green, and magenta) correspond to clinical evaluations at MedOFF/StimOFF, MedOFF/StimON, MedON/StimON, and MedON/StimON, respectively. Right side: Amplitude spectrum of the LFPs of both the left and right STN extracted as the mean of the ± 10-min interval around the evaluation point (MedOFF/StimOFF, MedOFF/StimON, MedON/StimON, and MedON/StimON) obtained at the time indicated in the left side panels. Please note that, in MedOFF-StimOFF, a clear beta peak is present in the left STN of patients 01 and 02 and the right STN of patient 03. This beta peak was disappeared by the stimulation.