Table 3.

Plasma BNP level in the diagnosis of PDA in neonates.

References	n	Gestational age (weeks)	Age	BNP cutoff value (ng/L)	Sensitivity (%)	Specificity (%)
Sanjeev et al. (60)	14	24–31	2–28 d	70	92.9	73.3
Choi et al. (61)	66	25–34	3 d	1,110	100	95.3
Flynn et al. (62)	20	24–35	4–5 d	300	52	100
Czernik et al. (63)	67	<28	2 d	550	83	86
Kalra et al. (64)	52	<34	3–7 d	122.5	100	100
Kim and Shim (65)	28	<37	4 d	412	100	95
Lee et al. (66)	73	Median 27.1	24 h	200	83.9	61.9
Lee et al. (66)	73	Median 27.1	24 h	900	54.8	95.2
Mine et al. (67)	46	<33	24–48 h	550	83	86
Gao et al. (68)	63	<34	2–3 d	292.5	75.4	77.6
Lee et al. (69)	63	<35	3 d	722	–	–
Parra-Bravo et al. (70)	29	<32	3–5 d	486.5	81	92