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. 2021 Dec 7;12:690371. doi: 10.3389/fphar.2021.690371

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Copyright © 2021 Hu, Wang, Liu, Zhang, Chen, Zhang, Tang, Qu, Tang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NaHS attenuated the Warburg effect in the left atrium gained from rats under Ang-II treatment. Representative Western blotting and relative densitometry analysis of (A) PDH, (B) LDHA and (C) PDK-4 with GAPDH as a loading control in the rats left atrial tissue of the indicated groups. Lactate acid (D) and the production of ATP (E) and glucose consumption (F) were determined by kit analysis in the rats left atrial tissue of the indicated groups ( n = 6 in each group). **p < 0.01 VS Sham, *p < 0.05 VS Sham, #p < 0.01 VS Ang II, &p < 0.05 VS Ang II. Groups were compared using one-way analysis of variance (ANOVA) (Tukey’s) in (A–F).