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The regulation network of Ikaros. The activated preBCR pathway decreases the activity of Ikaros, Ikaros counteracts this inhibition by repressing LYN and SHIP in the pathway; Notch3 upregulates HuD to convert Ikaros to the dominant negative isoform, and Ikaros counteracts the Notch effect on CSL activation through competing with the CSL DNA binding site in the promoter region.
