TABLE 1.
Bioassays in wild-type rodents and Tg mice expressing wild-type and mutant PrP molecules
| Host | Inoculum | Age of onset or incubation period (days ± SEM) | n/n0a |
|---|---|---|---|
| Syrian hamsters | None | >300 | 0/10 |
| Sc237 hamster prions | 74 ± 1 | 52/56 | |
| SHa synPrP61-Kma peptide | >300 | 0/6 | |
| Tg(SHaPrP)3922HOZ/Prnp0/0 mice | None | >500 | 0/10 |
| Sc237 hamster prions | 45 ± 2 | 8/8 | |
| SHa synPrP61-Kma peptide | >500 | 0/10 | |
| CD-1 mice | None | >500 | 0/10 |
| RML murine prions | 132 ± 1 | 29/29 | |
| Mo synPrP61-Kma peptide | >410 | 0/10 | |
| Mo synPrP61(P101L)-Kma peptide | >410 | 0/9 | |
| Tg(MoPrP-A)4053/Prnp0/0 mice | None | >700 | 0/20 |
| RML murine prions | 50 ± 2 | 16/16 | |
| Mo synPrP61-Kma peptide | >500 | 0/10 | |
| Mo synPrP61(P101L)-Kma peptide | >500 | 0/5 | |
| Tg(MoPrP P102L)196/Prnp0/0 mice | None | 613 ± 34 | 9/32 |
| RML murine prions | 229 ± 6 | 6/6 | |
| Mo synPrP61-Kma peptide | >50∗ | 0/10 | |
| Mo synPrP61(P101L)-Kma peptide | >410 | 0/8 | |
| Tg(PrP106)4290/Prnp0/0 mice | None | >500 | 0/7 |
| RML murine prions | 300 ± 22 | 8/8 | |
| PrP106 murine prions | 66 ± 3 | 40/40 | |
| Mo synPrP61-Kma peptide | >450 | 0/9 | |
| Mo synPrP61(P101L)-Kma peptide | >450 | 0/9 |
a
n, number of mice that developed disease; n0, number of inoculated mice. An asterisk represents an ongoing experiment.