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. 2021 Dec 21;2021(12):CD013139. doi: 10.1002/14651858.CD013139.pub2

Dunn 2019.

Study characteristics
General information Objective 
  • Prediction model compared


Journal
  • Surgery Research and Practice


Country
  • USA


Study design
  • Retrospective cohort study

Participants Number of included patients
  • 503


Surgical specialty
  • Kidney transplant surgery


Age
  • Median 52 years (IQR = 42 to 61)


Male sex
  • 58.4%


High‐risk surgery
  • Not reported


Insulin‐dependent diabetes mellitus
  • 28.4%


History of ischaemic heart disease
  • Not reported


History of congestive heart failure
  • Not reported


History of cerebrovascular events
  • Not reported


Elevated creatinine
  • Not reported


0 RCRI factors
  • Not reported


1 RCRI factor
  • Not reported


2 RCRI factors
  • Not reported


3 or more RCRI factors
  • Not reported

Predictors Predictor 1:
ASC‐NSQIP‐MICA
  • Objective: prediction model compared

  • Category: prediction model

  • Scale: not applicable

  • Threshold: not applicable

  • Assay/device: not applicable


 
Predictor 2:
PORT model
  • Objective: prediction model compared

  • Category: prediction model

  • Scale: not applicable

  • Threshold: not applicable

  • Assay/device: not applicable

Outcome Outcome category
  • Myocardial infarction and cardiac arrest


Full outcome definition
  • Not applicable


Prediction horizon
  • 30 days and one‐year events

Analysis Number of outcomes
  • 31        


Handling missing data
  • No information on handling missing data


Discrimination reported?
  • No


Calibration reported?
  • No


Reclassification reported?
  • No

PROBAST: Applicability Domain 1: Participant selection
  • High


Justification: only kidney transplants
Domain 2: Predictors
  • High


Justification: definition of ischaemic heart disease is different from the definition in the development study and no information on blinding
Domain 3: Outcome
  • High


Justification: outcome is myocardial infarction and cardiac arrest, which is different from the definition from the development study
Overall judgement
  • High


Justification: only a selected group of patients was included; predictor definitions were different from the predictor definitions used in the development study. In addition, outcome definition was different compared to the development study.
Notes
 
Item Authors' judgement Support for judgement
Domain 1: Participant selection Yes Although only patients undergoing kidney transplant surgery were included, participant selection was appropriate and the RCRI model can be applied in these patients.
Domain 2: Predictors No Definition of ischaemic heart disease is different from the definition in the development study and no information on blinding.
Domain 3: Outcome Unclear No information on how myocardial infarction is defined/diagnosed.
Domain 4:  Analysis No Low number of outcomes; complete case analyses; c‐statistic was not provided for the RCRI alone; no information on calibration and reclassification.
Overall judgement No Patient selection was appropriate. However, predictors were defined differently compared to predictor definitions used in the development study. In addition, the number of outcomes was low, complete case analysis was performed and no calibration and reclassification was reported.