NCT03436238.

Study name	Myocardial Injury in Noncardiac Surgery in Sweden (MINSS)
Starting date	15 May 2017
Contact information	Michelle Chew, Professor, Senior Consultant, Linkoeping University
Notes	The purpose of this multicentre, prospective, observational study is to identify robust biochemical markers that predict adverse cardiovascular outcomes and mortality in patients undergoing major abdominal surgery. Plasma levels of hsTnT, NTproBNP, copeptin, MR‐proADM and CT‐proET1 will be measured. Receiver operating curve analysis will be used to determine the optimal threshold of each biomarker in predicting mortality/MACCE. The net reclassification index will be used to assess if biomarkers confer added value to the RCRI for the classification of MACCE.

6MWT: six‐minute walk test; ASA: American Society of Anesthesiologists; BNP: brain natriuretic peptide; MACCE: major adverse cardiac and cerebrovascular events; MET: metabolic equivalents; MICA: myocardial infarction or cardiac arrest; NSQIP: National Surgical Quality Improvement; POSSUM: Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity; RCRI: Revised Cardiac Risk Index