Table 3.
Haemodynamic response to RSI in patients anaesthetised with standardised dosing regimen of fentanyl, ketamine and rocuronium
| Average baseline | Average Post-RSI | Absolute difference (95% CI) | P value | |
| All patients (n=322) | ||||
| HR (beats/min) | 97 (26) | 110 (23) | +13 (9–17) | <0.001 |
| SBP (mm Hg) | 142 (34) | 132 (35) | −10 (−13 to −6) | <0.001 |
| MAP (mm Hg) | 107 (25) | 100 (27) | −7 (−9 to −4) | <0.001 |
| Hypotensive response | 29 (9.0%) 22 (6.6%) |
|||
| Hypertensive response | ||||
| Full-dose RSI (n=204) | ||||
| HR (beats/min) | 97 (26) | 108 (23) | +13 (12–14) | <0.001 |
| SBP (mm Hg) | 151 (31) | 138 (34) | −12 (−16 to −7) | <0.001 |
| MAP (mm Hg) | 113 (23) | 104 (26) | −8 (−11 to −4) | <0.001 |
| Hypotensive response | 17 (8.3%) 16 (7.8%) |
|||
| Hypertensive response | ||||
| Reduced-dose RSI (n=118) | ||||
| HR (beats/min) | 98 (26) | 111 (24) | +13 (6–19) | <0.001 |
| SBP (mm Hg) | 126 (33) | 120 (35) | −6 (−11 to −1) | 0.09 |
| MAP (mm Hg) | 96 (24) | 92 (27) | −4 (−8 to 0) | 0.03 |
| Hypotensive response | 12 (10.2%) 6 (5.9%) |
|||
| Hypertensive response | ||||
| Isolated head injury (n=137) | ||||
| HR (beats/min) | 97 (26) | 104 (23) | +8 (2 to 14) | 0.008 |
| SBP (mm Hg) | 146 (32) | 134 (32) | −12 (−16 to −6) | <0.001 |
| MAP (mm Hg) | 108 (24) | 101 (26) | −7 (−11 to −3) | <0.001 |
| Hypotensive response | 8 (5.8%) 10 (7.3%) |
|||
| Hypertensive response | ||||
| Code red patients (n=30) | ||||
| HR (beats/min) | 96 (30) | 117 (25) | 22 (7 to 38) | 0.007 |
| SBP (mm Hg) | 109 (24) | 101 (27) | −9 (−20 to 1) | 0.093 |
| MAP (mm Hg) | 86 (20) | 80 (22) | −6 (−15 to 1) | 0.112 |
| Hypotensive response | 3 (10%) 0 (0%) |
|||
| Hypertensive response | ||||
Categorical data are reported as frequency (n) and percentage (%) and numerical data as mean (SD), or absolute difference (95%).
MAP, mean arterial pressure; RSI, rapid sequence induction; SBP, systolic blood pressure.