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. 2021 Dec 7;12:766405. doi: 10.3389/fgene.2021.766405

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Copyright © 2021 Ostner, Carcy and Müller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Credible changes found by tascCODA (λ ₁ = 1), comparing healthy controls and IBS patients in the genus-aggregated data of Labus et al. (2017). The circles on nodes of the tree represent credible effects. (A) High-level aggregation with ϕ = − 5. (B) Unbiased aggregation (ϕ = 0). (C) Aggregation with bias towards the leaves (ϕ = 5). Red genera show the credible effects found by scCODA (FDR = 0.1) on the genus level. The grey genus Alistipes was used as the reference for tascCODA and scCODA.