Fig. 3.

Effects of PGBF on total DCA + conjugates, total primary BAs, and total BAs in patients with NASH.

(A) Percentage change from baseline of DCA + conjugates and total primary BAs; error = bootstrapped 95% CI. (B) Fraction of DCA + conjugates and total primary BAs relative to total serum BAs. (C) Percentage change from baseline total serum BAs from study NCT02413372. Whiskers extend to most extreme data point that is ≤1.5× the IQR from the box. BA, bile acid; D, day; DCA, deoxycholic acid; NASH, non-alcoholic steatohepatitis; PGBF, pegbelfermin; QD, once daily; QW, once weekly.