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. 2021 Nov 12;4(1):100392. doi: 10.1016/j.jhepr.2021.100392

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Effects of PGBF on C4 concentration and LDL/HDL ratio in patients with NASH.

(A) Percentage and (B) absolute change in C4. (C) Percentage change in LDL/HDL ratio. (D) Correlation between percentage change in C4 from baseline to Day 112 and percentage change in LDL/HDL ratio from baseline to Day 112 from study NCT02413372. In (A), error = bootstrapped 95% CI; in (B and C), whiskers extend to most extreme data point that is ≤1.5× the IQR from the box. C4, 7α-hydroxy-4-cholesten-3-one; D, day; NASH, non-alcoholic steatohepatitis; PGBF, pegbelfermin; QD, once daily; QW, once weekly.