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. 2021 May 17;12(1):111–116. doi: 10.1177/19418744211016709

Table 1.

Clinical Profile of Reported Patients With Post-COVID-19 Miller Fisher Syndrome.

Author(s) Age/sex Neurological findings Gap from the COVID-19 onset (in days) EMG/Nerve conduction studies Neuroimaging SARS-CoV-2 in cerebrospinal fluid Anti-ganglioside antibody testing Specific therapy Outcome
3 50/M Anosmia, ageusia, internuclear ophthalmoparesis, right fascicular oculomotor palsy ataxia and areflexia 5 Not reported Normal unenhanced CT scan of the brain Negative Positive (anti-GD1b–IgG) Intravenous immunoglobulin Resolution within two weeks
5 36/M Left eye drooping, blurry vision, reduced sensation, paresthesia in both legs to all modalities below knee level, partial left third nerve, bilateral sixth nerve palsy and areflexia 4 Not reported Enlargement and T2 hyperintensity, and enhancement of the affected third cranial nerve from the cavernous sinus through the orbit on MRI Not reported Positive Intravenous immunoglobulin Resolution after one week
6 51/F Intense root-type pain in all four limbs, dorsal and lumbar back pain, weakness in her lower limbs, double binocular vision (left sixth cranial nerve palsy), bilateral facial paresis, symmetrical paraparesis, global areflexia and autonomic dysfunction 15 Guillain-Barre type demyelinating polyneuropathy Normal Not reported Negative Intravenous immunoglobulin Progressive improvement
7 63/M Perioral and fingertips paresthesias, diplopia, divergent squint, areflexia and ataxic gait 1 Not reported Not reported Not reported Not reported Intravenous immunoglobulin Self-limiting illness
8 50/F Ataxia, ophthalmoplegia, left upper arm cerebellar dysmetria, generalized areflexia, mild lower facial defects and mild hypoesthesia over face 16 Not reported Normal Not reported Negative Intravenous immunoglobulin Complete resolution within 14 days
9 36/M Partial left oculomotor palsy, bilateral abducens palsies, lower limbs hyporeflexia, hypoesthesia and gait ataxia 4 Not reported Enhancement and T2-hyperintensity and enlargement of the left oculomotor nerve on MRI Not reported Negative Intravenous immunoglobulin Partially complete resolution
10 45/M Ataxia, ophthalmoplegia, areflexia and tetraparesis 16 Not reported Intrathecal cauda-equina enhancement on MRI Not reported Positive Intravenous immunoglobulin During report writing still needed respiratory support. Partially improvement of neurological picture
11 74/F Lower limbs areflexia with patent gait ataxia 15 Slight F-wave delay in upper limbs Normal MRI Negative Negative Intravenous immunoglobulin Improved
12 61/M Ophthalmoplegia, generalized areflexia and sensory ataxia 20 F-wave was not detectable Not reported Negative Negative Intravenous immunoglobulin Improved
13 31/F Ophthalmoplegia, ataxia, areflexia and dysmetria 3 Not reported Normal Positive Positive Convalescent plasma, tocilizumab and intravenous immunoglobulin Mild improvement
14 50/M Dysmetria, dysdiadochokinesia and absent upper limbs reflexes 1 Not performed Normal Negative Negative Intravenous immunoglobulin Some improvement, before developing ventricular arrhythmia and cardiac arrest unexpectedly.
Current case 55/F Dysautonomia, ataxia, ophthalmoplegia, areflexia, and paresthesias involving perioral areas and fingers/toes 15 Normal Normal MRI Not reported Positive Intravenous immunoglobulin Complete resolution, except generalized hyporeflexia