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. 2021 Dec 7;12:771499. doi: 10.3389/fphys.2021.771499

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Copyright © 2021 Kiriaev, Kueh, Morley, North, Houweling and Head.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maximum tetanic and twitch force. (A) Interleaved scatterplot of the maximum absolute force generated by EDL muscles across 4-month (n = 14 control; n = 12 mdx), 9-month (n = 11 control; n = 13 mdx), 15-month (n = 14 control; n = 10 mdx), 18-month (n = 12 control; n = 14 mdx), and 22-month (n = 10 control; n = 11 mdx) age groups. (B) Interleaved scatterplot of the maximum specific force (force per physiological cross-sectional area) generated by EDL muscles across 4-month (n = 14 control; n = 9 mdx), 9-month (n = 11 control; n = 12 mdx), 15-month (n = 14 control; n = 10 mdx), 18-month (n = 12 control; n = 14 mdx), and 22-month (n = 10 control; n = 11 mdx) age groups. (C) Interleaved scatterplot of the twitch force generated by EDL muscles across 4-month (n = 14 control; n = 9 mdx), 9-month (n = 11 control; n = 16 mdx), 15-month (n = 14 control; n = 14 mdx), 18-month (n = 12 control; n = 13 mdx), and 22-month (n = 10 control; n = 12 mdx) age groups. (D) Interleaved scatterplot of the twitch specific force generated by EDL muscles across 4-month (n = 14 control; n = 9 mdx), 9-month (n = 11 control; n = 16 mdx), 15-month (n = 14 control; n = 14 mdx), 18-month (n = 12 control; n = 13 mdx), and 22-month (n = 10 control; n = 12 mdx) age groups. In each group the horizontal line indicates the mean value ± SD. Statistical differences between age groups are displayed above the graph, statistical differences displayed within graphs are differences between genotypes assessed by two-way ANOVA, post hoc analysis using Sidak’s multiple comparisons test. ****P < 0.0001, ***0.0001 < P < 0.001, **0.001 < P < 0.01, and *0.01 < P < 0.05.