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. 2021 Dec 7;12:771499. doi: 10.3389/fphys.2021.771499

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Copyright © 2021 Kiriaev, Kueh, Morley, North, Houweling and Head.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Force frequency curves. (A) Aggregated force frequency curves from EDL muscles to visualize differences between genotype across 4-month (n = 7 control; n = 7 mdx), 9-month (n = 6 control; n = 7 mdx), 15-month (n = 7 control; n = 6 mdx), 18-month (n = 6 control; n = 7 mdx), and 22-month (n = 6 control; n = 7 mdx) age groups. Muscle absolute force was measured at different stimulation frequencies and a sigmoidal curve (lines) was fitted to the data points (see section “Materials and Methods”), contractile properties were generated from these curves (see Table 1). (B) For clarity 4-month and 22-month old age groups have been isolated to highlight the shape and slope of these force frequency curves. Data shown in these curves are mean only, SD was omitted for visual clarity.