Table 3.

Number of drugs with five or more PI change orders by WHO ATC/DDD index.

WHO ATC/DDD index	Number of drugs
	PMACS	No PMACS
Antineoplastic and immunomodulating agents	6	2
Anti-infectives for systemic use	2	9
Nervous system	1	5
Musculo-skeletal system	1	1
Alimentary tract metabolism	0	1
Blood and blood forming organs	0	1
Cardiovascular system	0	1

Among drugs with reexamination reports issued from 2017 to 2019, those with five or more PI change orders during their reexamination period were accumulated, categorized by WHO ATC/DDD index and compared based on mandatory status of PMAC.

PMACS, postmarketing all-case surveillance; WHO ATC/DDD, World Health Organization anatomical therapeutic chemical and defined daily dose.