| 2001 |
first commercial system
designed for BLI of small animals (IVIS, Xenogen Corporation) |
(75) |
| 2003 |
first bioluminescence tomography
(BLT) prototype developed, enabling integration with CT for quantitative
3D localization of signals |
(76) |
| 2006 |
development of spectral
unmixing algorithms for separating signals from multiple BLI reporters |
(77) |
| 2008 |
new imaging system developed
for video-rate imaging of nonanaesthetized and freely moving mice |
(72) |
| 2012 |
first time multiple BLI
reporter genes were imaged in vivo using BLT
|
(78) |
| 2013 |
development of a 3D BLI
method based on multiple rotating cameras for accelerated data acquisition
and improved signal quantification |
(79) |
| 2018 |
video-rate imaging of Akaluc-expressing
striatal neurons in nonanaesthetized marmosets using a MIIS system
(Molecular Devices Japan) |
(27) |
| 2020 |
in vivo BLI in the second near-infrared region (1000–1700 nm) achieved using a InGaAs CCD camera (Princeton Instruments, NIRvana-LN) |
(80) |
