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. 2002 Oct 21;2002(4):CD002992. doi: 10.1002/14651858.CD002992

Butland 1983.

Methods Longer duration: 4 weeks treatment and placebo 
 Cross‐over 
 Double‐blind 
 Dropout: 0%
Participants n = 12 
 Mean age = 61 
 Inclusion: reversible COPD: FEV1 < 1 L with > 20% reversal. Could continue taking inhalers, steroids. 
 Exclusion: other lung disease or serious disease of other organs
Interventions Atenolol 100 mg/d 
 Metoprolol 100 mg/d 
 Placebo
Outcomes Symptoms 
 Exercise tolerance
Notes FEV1 reported only as % of predicted normal value