Figure 1.

A, Hypothetical patient report for whole-genome sequencing, including lineage/clade designations, coding mutations, variant allele frequency, depth of coverage or fold coverage, and clinical interpretation. B, Example report for the same specimen tested using allele-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR). Abbreviations: COVID, coronavirus disease; DOC, depth of coverage; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; VAF, variant allele frequency; WHO, World Organization; #, lineage defining.