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. 2021 Nov 10:jiab561. doi: 10.1093/infdis/jiab561

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© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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Figure 2. — Vaccinated hamsters are protected from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated weight loss and lung pathology. (A) Animals were monitored for weight for 5 days after challenge. Means (±standard error of the means [SEMs]) are shown for each group. (B) Lung weights on day 5 were taken and normalized by the actual animal weight to calculate a percentage of body weight. Means (±SEMs) are shown for each group, one-way analysis of variance statistical analysis was performed among the groups, with all groups compared with the no vaccine group. (C) Histology scores of lungs. (D) Histopathology of the lungs. Lung lobes were collected, trimmed, and processed routinely, paraffin embedded, sectioned at 4 µm, and stained with hematoxylin and eosin for microscopic examination.