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. 2021 Nov 12;50(D1):D687–D692. doi: 10.1093/nar/gkab1028

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Drugs that potentially target SARS-CoV-2. (A) The pathway ‘Potential therapeutics for SARS’ (R-HSA-9679191, https://reactome.org/content/detail/R-HSA-9679191) is a systematic catalog of drug binding reactions; the binding of dexamethasone and other NR3C1 (glucocorticoid receptor) agonists to a complex including NR3C1 protein (R-HSA-9678925, https://reactome.org/content/detail/R-HSA-9678925), outlined in red is enlarged in (B), which also shows the full list of small-molecule NR3C1 agonists annotated in Reactome. The effect of this binding on the HSP90 chaperone complex (R-HSA-9690534, https://reactome.org/content/detail/R-HSA-9690534) is shown in (C).