Table 1.

Reactome content, version 70 (9/2019) (4) versus 78 (9/2021).

Data type	Release 70	Release 78	Change
Human proteins	10 867	10 726	-141a
Proteoforms	25 849	29 466	3617
Chemicals	1856	1940	84
Reactions	12 608	13 890	1282
Human disease proteins	308	352	44
Disease variants	1599	4603	3004
Chemical drugs	217	468	251
Protein drugs	5	39	34

^aWe have temporarily removed a group of 352 orphan olfactory GPCRs that previously were annotated as pre-associated with G-proteins because this reaction mechanism has not been demonstrated for olfactory GPCRs (6,7). Current work to annotate the epigenetic selection of individual olfactory GPCRs for expression will restore the expressed orphan olfactory GPCRs to the database (8), bringing the change in number of annotated proteins since release 70 to + 212.