Table 3.

Demographic and Clinical Descriptions of Patients with Multisystem Inflammatory Syndrome in Adults Who Received a COVID-19 Vaccine, December 2020 to April 2021, United States

Patient	Age Group (years), sex	Race, Ethnicity	Onset Year	Serology	PCR	Clinical Features/ Imaging/ Complications	Treatment
1	20–24, Female	White, non-Hispanic	2021	Nucleocapsid positive	Positive	Shock, shortness of breath, abdominal pain, diarrhea, neck pain, myalgia, cervical lymphadenopathy > 1.5cm Echocardiography: LV dysfunction, EF 48%, pericardial effusion, ECG (T wave inversion), congestive heart failure, myopericarditis	Corticosteroids, IVIG ×1
2	20–24, Female	White, non-Hispanic	2021	Nucleocapsid positive	Positive	Shock, cough, shortness of breath, abdominal pain, diarrhea, elevated bilirubin/liver function tests Echocardiography: LV dysfunction, pericardial effusion Abdominal CT: mesenteric lymphadenopathy Chest CT: pneumonia, pleural effusion congestive heart failure, myocarditis	HFNC, vasoactive medication, corticosteroids, antiplatelet medication, IVIG ×2
3	30–34, Female	White, non-Hispanic	2020	Nucleocapsid positive	Positive	Shock, cough, abdominal pain, vomiting, diarrhea, rash, myalgia, elevated LFTs Echocardiography: LV dysfunction, EF 44%, mild LV hypertrophy, mild pulmonary hypertension, mild pericardial effusion Chest CT/X-ray: pneumonia ECG (non-specific ST seg change, abnormal T-wave), congestive heart failure	HFNC, corticosteroids
4	35–39, Male	White, non-Hispanic	2021	Nucleocapsid positive	Negative	Shock, abdominalpain, vomiting, diarrhea, rash,headache, myalgia, conjunctival injection, cervical lymphadenopathy, altered mental status Elevatedbilirubin/liver function tests Echocardiography: LV/RV dysfunction, pericardial/pleural effusion, mitral regurgitation Chest X-ray: patchy airspacedisease congestive heart failure, myocarditis, AKI	Mechanical ventilation, ECMO, vasoactive medication, corticosteroids, antiplatelet medication, IVIG ×2
5	45–49, Female	Multiple races, non-Hispanic	2021	Nucleocapsid positive	Positive	Shortness of breath, diarrhea, rash, mucocutaneous lesions, encephalopathy, myalgia Elevated liver function tests Echocardiography: normal Chest CT: atelectasis Encephalitis or aseptic meningitis, AKI	Non-invasive ventilation, corticosteroids, antiplatelet medication, IVIG ×1
6	45–49, Male	Black, non-Hispanic	2021	Not done	Positive	Shock, cough, shortness of breath, chest pain, abdominal pain, diarrhea, headache, encephalopathy Elevated bilirubin/liver function tests, Echocardiography: cardiac dysfunction, reduced EF Abd CT: enlarged liver Chest CT: ground glass infiltrates, pneumonia, pleural effusion Arrhythmia (supraventricular), congestive heart failure, encephalitis or aseptic meningitis, AKI	Noninvasive ventilation, vasoactive medication, corticosteroids, tocilizumab, anticoagulation medication, IVIG ×1
7	45–49, Female	Black, non-Hispanic	2021	Nucleocapsid positive	Positive	Shock, cough, chest pain, abdominal pain, vomiting, diarrhea, headache, syncope or near syncope, encephalopathy, cervical lymphadenopathy > 1.5 elevated bilirubin/liver function tests Echocardiography: LV/RV dysfunction, EF 25%, pericardial effusion, severe global LV hypokinesis Abdominal ultrasound: gallbladder thickening and trace pericholecystic fluid Chest X-ray: pleural effusion, opacity Congestive heart failure, myopericarditis, AKI, renal failure,	Mechanical ventilation, vasoactive medication, corticosteroids, anakinra, IVIG ×2

Abbreviations: AKI, acute kidney injury; CT, computed tomography; ECG, electrocardiogram; ECMO, extracorporeal membrane oxygenation; EF, ejection fraction; HFNC, high-flow nasal canula; IVIG, intravenous immune globulin; LFT, liver function test; LV, left ventricle; RV, right ventricle.