Table 5.
Comparison of characteristics of people with AKI-RRT from waves 1 and 2 of the COVID-19 pandemic
| Characteristic | Wave 1, n = 138, n (%) | Wave 2, n = 133, n (%) | P value |
|---|---|---|---|
| Demographics | |||
| Male | 105 (76) | 101 (76) | 0.977 |
| Age group | 0.024 | ||
| 29–69 years | 98 (71) | 77 (58) | |
| 70+ years | 40 (29) | 56 (42) | |
| Comorbid conditions | |||
| Diabetes mellitus | 71 (51) | 58 (44) | 0.196 |
| Cancer | 13 (9) | 12 (9) | 0.910 |
| Cardiac disease | 21 (15) | 33 (25) | 0.048 |
| CKDa | 0.045 | ||
| eGFR <59 mL/min/1.73 m2 | 27 (20) | 38 (29) | |
| eGFR 60–89 mL/min/1.73 m2 | 58 (42) | 53 (40) | |
| eGFR 90+ mL/min/1.73 m2 | 53 (38) | 42 (32) | |
| Treatment received | |||
| ICU admission | 133 (96) | 126 (95) | 0.578 |
| On ventilator | 133 (96) | 119 (90) | 0.047 |
| Time to RRT initiation from positive COVID-19 swab | <0.001 | ||
| Within 1 week | 71 (51) | 43 (32) | |
| 1–2 weeks | 37 (27) | 37 (28) | |
| After 2 weeks | 20 (14) | 45 (34) | |
| Missing | 10 (7) | 8 (6) | |
| Median (IQR), days | 7 (3–12) | 12 (4–16) | |
| Recovery of renal function | 39 (28) | 45 (34) | 0.321 |
| Incidence of deaths by time after initiation of RRT | 0.225 | ||
| Within 0–7 days | 39 (28) | 46 (35) | |
| Within 8–14 days | 18 (13) | 20 (15) | |
| Within 15–28 days | 19 (14) | 14 (11) | |
| After 28 days | 11 (8) | 7 (5) | |
| Total mortality | 87 (63) | 87 (66) |
a
Baseline eGFR within 7 days to 3 years prior to dialysis start.
The first wave (wave 1) of the pandemic in Ontario comprised the period 1 March to 1 September 2020, and the second wave (wave 2) from 1 September 2020 to 31 January 2021.
P-values were calculated using the Chi-squared test for analysis of categorical variables. eGFR, estimated glomerular filtration rate.