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. 2021 Dec 20;19:521. doi: 10.1186/s12967-021-03178-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — SIRT5 is downregulated and associated with the prognosis of patients with ccRCC. A SIRT5 expression in tumor and normal tissues in TCGA-KIRC dataset. B SIRT5 expression in 72 paired ccRCC tissues from TCGA-KIRC cohort. SIRT5 expression levels were compared in groups stratified by different clinicopathological parameters: TNM stage (C–E), tumor grade (F) and pathological stage (G). H Kaplan–Meier analysis of OS of patients stratified by SIRT5 expression in TCGA-KIRC dataset. Cluster dendrograms (I), soft thresholds (J) and module-trait relationships (K) were analysed using WGCNA. L GO functional enrichment analysis. M KEGG pathway analysis