Table 4.

Reliability measures of endoscopic and histological investigations for the diagnosis of acute gastro-intestinal-graft versus host disease (GI-GVHD)

	Sensitivity	Specificity	PPV	NPV	K	Concordance
Esophagus-gastro-duodenoscopy	1.0 (0.8–1.0)	0.3 (0.1–0.5)	0.4 (0.2–0.6)	1.0 (0.8–1.0)	0.24	Low
“Upper” histology	0.6 (0.4–0.8)	0.7 (0.6–0.9)	0.6 (0.4–0.7)	0.8 (0.6–0.9)	0.42	Moderate
Rectum-sigmoidoscopy	0.8 (0.5–0.9)	1.0 (0.7–1.0)	1.0 (0.8–1.0)	0.5 (0.3–0.7)	0.56	Moderate
“Intestinal” histology	0.8 (0.6–0.9)	1.0 (0.8–1.0)	1.0 (0.8–1.0)	0.6 (0.3–0.8)	0.68	Good

(95% CI); K di Cohen: <0.01 = null; 0.01–0.20 = poor; 0.21–0.40 = minor; 0.41–0.60 = moderate; 0.61–0.80 = high; 0.81–1.00 = excellent. PPV, positive predictive value; NPV, negative predictive value.