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. 2022 Jan 1;12(1):379–395. doi: 10.7150/thno.67034

Figure 2.

Figure 2

Effect of Smad3KO or WT islet transplantation on renal injury in STZ-induced diabetic mice at week 16 post-transplantation. (A) Periodic Acid-Schiff (PAS) staining shows the glomerular mesangial expansion. (B) Immunohistochemistry detects the expression of Col1a1. (C) Quantitation of the glomerular mesangial area as shown in panel A. (D) Quantitation of the Col1a1 expression as shown in panel B. (E) Determination of 24 h total urinary protein. (F) Quantitation of serum creatinine. Each dot represents one animal. ND, non-diabetic normal control. *p < 0.05, **p < 0.01, and ***p < 0.001 versus ND group. #p < 0.05, ##p < 0.01, and ###p < 0.001 versus sham group. $p < 0.05, $$p < 0.01, and $$$p < 0.001 versus Smad3WT 100 group. Scale bar, 25 μm.