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. 2022 Jan 1;12(1):379–395. doi: 10.7150/thno.67034

Figure 3.

Figure 3

Transplantation with Smad3KO islets attenuates hyperglycemia and glucose intolerance in db/db mice. (A, B) Weekly RBG and FBG; (C, E) IPGTT and its AUC quantitation. (D, F) IPITT and its AUC quantitation. (G) Levels of HbA1c. (H) Serum levels of insulin. Animal numbers used for islet treatment (A to D) are indicated in the up panel of the figure. Each dot represents one animal for E to H. Data are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 versus age-matched db/m mice. #p < 0.05, ##p < 0.01, ###p < 0.001 versus sham-db/db mice. $p < 0.05, $$p < 0.01 versus db/db mice receiving Smad3WT islets.