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. 2022 Jan 1;12(1):379–395. doi: 10.7150/thno.67034

Figure 4.

Figure 4

Effect of Smad3KO and WT islet transplantation on renal injury in db/db mice at the age of week 12 (8 weeks treatment over week 4 to 12). (A) Periodic Acid-Schiff (PAS) staining shows the glomerular mesangial expansion. (B) Immunohistochemistry detects expression of Col1a1. (C) Quantitation of the glomerular mesangial area as shown in panel A. (D) Quantitation of the Col1a1 expression as shown in panel B. (E) Determination of 24 h total urine protein. (F) Quantitation of serum creatinine. Each dot represents one animal. * p < 0.05 versus age-matched db/m mice. #p < 0.05 versus Smad3WT db/db mice. Scale bar, 25 μm.