Figure 2.
circDNA aptamers for versatile disease theranostic applications. (A) Synthesis scheme of bispecific circDNA aptamer for bispecific recognition of His tagged protein cargoes and PTK7 on targeted cells. Reprinted from 23, copyright (2020) The Royal Society of Chemistry Publishing Group. (B) Preparation of bivalent circDNA ApDCs with accurate tunability of drug ratios for drug combination cancer therapy (DCCT). Reprinted from 25, copyright (2019) The Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. (C) Schematic illustration of the bispecific circDNA aptamer and (b) its molecular-mediated “recognition-then-activation” for targeted immunotherapy. Reprinted from 26, copyright (2020) The American Chemical Society Publishing Group.