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. 2022 Jan 1;12(1):340–361. doi: 10.7150/thno.65522

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nCHI3L1 Ab inhibits cell growth and migration in various cancer cell lines and reduces angiogenesis of endothelial cells in vitro. (A) Cell viability assay showing nCHI3L1 Ab decreased the proliferation induced by rCHI3L1. (B, C) Transwell migration assay showing nCHI3L1 Ab reduced the migration ability triggered by rCHI3L1. (D, E) Tube formation (Upper) and transwell migration (Lower) assays (D) and quantitative results (E) showing nCHI3L1 Ab reduced the in vitro angiogenesis ability of HUVEC endothelial cells triggered by rCHI3L1. Data represent mean ± SD. * p < 0.05; ** p < 0.01; *** p < 0.001, one-way ANOVA test.