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. 2022 Jan 1;12(1):277–289. doi: 10.7150/thno.63441

Figure 2.

Figure 2

Diabetic stress induces METTL3 expression in pericytes. (A and B) Retinal pericytes were incubated with normal culture medium (normal glucose, NG) or 25 mM glucose (high glucose, HG) for 24 h and 48 h. qRT-PCR assays and western blots were conducted to detect the levels of METTL3, METTL14, WTAP, VIRMA, RBM15, and ZC3H13. n = 4; *P < 0.05 versus NG group; 1-way ANOVA, Bonferroni test. (C and D) qRT-PCR assays and western blots were conducted to detect the levels of Mettl3 in the diabetic retinal vessels and the corresponding controls. The representative blots for Mettl3 were shown. n = 6 retinas per group; *P < 0.05 versus non-DM; Mann-Whitney U test, Bonferroni test.