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. 2022 Jan 1;12(1):362–378. doi: 10.7150/thno.65597

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FUS disrupted the BBB in a pig GBM model. (A) Hardware setup for MRI-guided sonobiopsy in pigs. The pig head was stabilized by the head supports. The MR-compatible motor enabled the translation of the FUS transducer to specific target locations. (B) Placement of pig in sonobiopsy device. (C) CE T₁-weighted MRI scan shows tumor volume (blue area) and FUS-induced BBB disruption (orange area). (D) The CE volume significantly increased (n = 6; p = 0.031; ^*p < 0.05; paired samples Wilcoxon signed rank test) from 348.70 ± 358.02 mm³ to 799.50 ± 501.19 mm³. Black bars indicate mean in D.