TABLE 2.

Effect of hypoxia on corneal stroma

Author	Models	Findings	Duration of hypoxia
Tina, et al. 32	3D in vitro culture of corneal fibroblasts isolated from healthy cornea stroma and keratoconus in hypoxic environment	Reduction of collagen I and III; Elevation of MMP‐1 and ‐2 expression	1 week
Pramod, et al. 37	Human corneal fibroblasts cultured in lower oxygen conditions (2%, 0.5%)	Highest extracellular matrix deposition in 2% oxygen tension groups	14 days
Xing, et al. 38	Bovine corneal stromal cells in hypoxia condition (0.5%)	Upregulation of HIF‐1α and VEGF	4 h