Table 3.

CpG sites differentially methylated in women with a history of hypertensive disorders of pregnancy. Top 20 most significant CpG sites. Sites that met the genome-wide significance criterion (p < 5 × 10⁻⁸) for both pre-eclampsia and gestational hypertension (starred*)

CpG	Beta	SE	p value	chr	Gencode Basic
cg20089264	0.0171	0.003	6.25 E − 11	chr22	ASCC2
cg16202187*	0.009	0.001	1.68 E − 10	chr19	HAUS8
cg14862827	0.011	0.002	1.79 E − 10	chr9
cg09020375	− 0.038	0.006	7.65 E − 10	chr4	ART3
cg23694630	− 0.039	0.006	9.20 E − 10	chr10
cg13081185	− 0.034	0.006	1.60 E − 09	chr11	SIK3
cg12522722	− 0.047	0.008	1.63 E − 09	chr11	ZW10;RP11-661I21.2
cg10918328*	0.018	0.003	2.64 E − 09	chr13	LINC00391
cg02068524	0.026	0.004	2.79 E − 09	chr4
cg08687948	− 0.027	0.005	3.09 E − 09	chr7	CYTH3;CYTH3
cg06853492	− 0.025	0.004	5.69 E − 09	chr2	RAPGEF4
cg17324671*	− 0.032	0.005	5.92 E − 09	chr2
cg26460602*	− 0.027	0.005	6.75 E − 09	chr19
cg05223360*	− 0.027	0.005	6.86 E − 09	chr1
cg15400652	− 0.019	0.003	8.20 E - 09	chr19	PSG2
cg09138430	0.016	0.003	1.04 E − 08	chr7	DBNL
cg23834489*	− 0.023	0.004	1.04 E − 08	chr17	PSMD3
cg04806794	0.028	0.005	1.11 E − 08	chr9	TLE4
cg18304195	0.026	0.004	1.40E − 08	chr3	KBTBD8
cg13709211*	− 0.044	0.008	1.92E − 08	chr14	MEG3