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. 2021 Dec 20;21:837. doi: 10.1186/s12884-021-04069-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — MiR-513c-5p was selected as a miRNA of interest based on the results of the bioinformatic analysis and RT-qPCR. The miR-513c-5p mimic suppressed cell proliferation, invasion and migration but promoted cell apoptosis in HTR-8/SVneo cells. The cell proliferative ability and cell apoptotic rate were determined at 24 h after transfection. A The EdU assay showed that the proliferation of HTR-8/SVneo cells was reduced by the miR-513c-5p mimic (n = 3). B Invasion assays revealed that the invasive ability was inhibited by the miR-513c-5p mimic. The Transwell chamber assay detected the changes in the invasive capabilities of HTR-8/SVneo cells. Compared to NC, trophoblast cells transfected with the miR-513c-5p mimic were significantly less invasive (P < 0.05). C The miR-513c-5p mimic inhibited the migration of HTR-8/SVneo cells, as analyzed using the wound healing assay. Quantitative analysis of the migration area was assessed. D The flow cytometry analysis revealed an increase in the percentage of apoptotic cells after transfection with miR-513c-5p mimics compared with NC